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The maximum dose used in the current study -- the equivalent of 60 milligrams -- is three times higher than the highest dose recommended for those over 60, he added.
At the maximum dose used (10−6 M OHT), 90±13% of colony-forming cells displayed a SABG+ signal (Fig. 3D), indicating that tamoxifen-mediated inactivation of ER can induce almost a complete senescence response in these cells (P<0.0001).
Addition of rotenone at 5 µM (maximum dose used) slightly raised the height of the standard curve at all points with no change in slope so the data were corrected for this factor.
* Maximum dose used in the experiments.
In conclusion, GS-101 eye drops are safe at the maximum dose used in this study, i.e. 143.3 µg per drop, three times daily.
An oral dose of 10 mg macitentan once daily was assessed in this study, which corresponds to the maximum dose used in the ongoing phase 3 program.
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Patients on oral medication were titrated to maximum dose using the following combinations: metformin alone, DPP4-inhibitors alone, sulfonylurea alone, metformin + DPP4-inhibitors, metformin + sulfonylurea, metformin + glinides, acarbose could be added to any of these combinations.
Second, the doses used in children are usually higher than the maximum doses used in adults (3).
Although no corresponding limit to the obtainable reduction in BP has been observed in the adult population, the higher dosages in this study far exceeded the maximum doses used to establish the efficacy and PK/PD relationship in adults [ 14].
The trial utilised a flexible dosing regime that was tailored to the clinical need of the patients, with high maximum doses, using the marketed formulation, under double-blind conditions.
Finally, we highlighted a potential association between the maximum epinephrine dose used and death with a 100%% death rate for an epinephrine maximum dose over 1.90 mg/kg/min.
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