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Each batch of recombinant RANKL was tested in dose response studies and the minimal dose that promoted maximal osteoclast differentiation of WT marrow (typically 50 ng/ml) was used for all of the experiments with the exception of the dose-response studies reported here, where the maximum dose tested (100 ng/ml) was twice the dose used for differentiation studies.
If the MTD was not exceeded within the planned dose levels, the MTD was defined as the maximum dose tested.
Both were found to be safe up to 2000 mg/kg which was the maximum dose tested.
If the MTD was not exceeded within the planned dose levels, MTD was defined as the maximum dose tested.
ApoE COG 133 peptide caused a significant reduction in the intestinal MPO levels at the maximum dose tested (3 μM) (p <0.05).
In the subgroup analysis, the two studies were assigned to a dose group according to the maximum dose tested in that study.
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Regulatory guidelines lack recommendations regarding safety margins for teratogenicity between NOAEL in EFD studies a and maximum doses tested in clinical trials.
On September 25 , 2004 three months after the chemical hit the market, the first-recorded 5-MeO-DALT overdose occurred when a Floridian user accidentally ingested 225 mg (more than 11 times the maximum dose Shulgin tested) in the midst of Hurricane Jeanne.
Overall, 22 patients were treated at the maximum dose level tested.> -wrap-foot> dose-limitingitoxicityicitoxicity
On days 1 and 5, at the maximum dose level tested, the azacitidine Cmax was 581 and 638 ng/ml, the t1/2 was 0.67 and 0.42 h, the clearance was 178 and 156 l/h/m, the volume of distribution was 121 and 94 l/m, and the AUC0-inf was 412 and 432 h-ng/ml, respectively.> -wrap-foot> aMedian = 259.2.
At the maximum dose level tested, the oxaliplatin Cmax was 650 ng/ml, the t1/2 was 16.5 h, the clearance was 24.5 l/h/m, the volume of distribution was 554 l/m, and the AUC0-inf was 1,456 h-ng/ml.> -wrap-foot> C max, maximum concentration; AUC, area under the curve; t 1/2, half-life of elimination; V d, volume of distribution; CL, clearance.
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