Sentence examples for maximum dose level from inspiring English sources

Since 6 animals in the 2% male group died of hemorrhage of several organs by week 50, the maximum dose level was changed to 1% in both sexes for the last 2 weeks.

Overall, 22 patients were treated at the maximum dose level tested.> -wrap-foot> dose-limitingitoxicityicitoxicity

In contrast, local toxicity was frequent and persistent with PTX s.c., and the maximum dose level tolerated was 10 mg kg−1 day−1 for 2 weeks.

The primary endpoint was safety and toxicity of Docetaxel concurrent with Radiation Therapy after induction treatment in order to define the maximum dose level.

If two or more subjects experienced a DLT at a dose level, that dose level was deemed the maximum dose level to be tested.

Once the MTD (or the maximum dose level) would have been achieved, the study was to continue as a phase II one to assess response and toxicity of the proposed schedule in a cohort of 15 patients.

Subsequent cohorts self-administered a micronised formulation of umbralisib tablet in a fed state at an initial dose of 200 mg, increased in increments to 400, 800, 1200, and 1800 mg until the maximum tolerated dose or the maximal dose level was accrued.

With no dose-limiting toxicities (DLTs) at maximum dose levels on Schedule 2/1, MTD was not reached.

Therefore, regimens with doses considered adequate but not at maximum dose levels of multiple agents may be sufficient for NSCLC patients, including the elderly.

A main cause for the better survival rates in the cohort treated after the year 2000 might be the improved radiotherapy technique with the introduction of 3D-CRT (3-dimensional conformal radiotherapy) with isocentric CT-planning at our institute in the year 2001 with maximum dose levels of up to 74 Gy in the tumor area replacing the 2D-SSD technique.

Maximum cell kill is best achieved by using the optimal (not necessarily the maximum tolerated) dose level as often as feasible considering the impact of the drug on host toxicity.