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The maximum dose in the spinal cord was below 40 Gy in all treatment plans.
Workers could receive a maximum dose in 15 minutes in some parts of the plant, where levels exceed 1,000 millisieverts per hour.
The maximum dose in the specimens was 0.9 dpa, which is sufficient to achieve steady-state creep without the structural changes that alter the observed creep behavior.
This means the tumor margin will receive 50% of the maximum dose in the target (Fig. 1).
We therefore used 100 μM of each C60 derivative as the maximum dose in the following in vitro assays.
In our experience, for non-monitorable and potentially irreversible and severe toxicities, a safety factor of ten is usually applied between exposure associated with the maximum dose in a clinical trial and the NOAEL in EFD studies.
Similar(35)
In the present investigation, using MMC at maximum doses in combination with infusional 5-FU, a low remission rate of 3% was observed.
A slightly higher proportion of patients in the previous PCI subgroup (81%) were taking ≥50% to <100% or ≥100% of the recommended maximum doses in comparison with the no previous PCI group (75%).
Maximum doses in each schedule (albiglutide 30 mg weekly, 50 mg biweekly, and 100 mg monthly) elicited similar responses in A1C, providing meaningful reductions within the range of ∼0.8 0.9% from a mean baseline A1C of 8.0%.
An oral dose of 10 mg macitentan once daily was assessed in this study, which corresponds to the maximum dose used in the ongoing phase 3 program.
In conclusion, GS-101 eye drops are safe at the maximum dose used in this study, i.e. 143.3 µg per drop, three times daily.
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