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The maximum deletion sequence for each frame, including for data shown in B, is represented in gray.
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For the investigation of sequences flanking each deletion, sequences 500 bp upstream of the deletion start and 500 bp downstream of the deletion end were considered.
Maximum- likelihood sequence estimation.
Maximum sequence length (length); Chromosome (chr).
The deleted sequences are shown by black hyphens, and the number of the deletions are showed on the right.
All patients with the intron 1 deletion were sequenced.
In a recent study, sequencing across the breakpoints of 23 deletions (2 37 kb, median 5836 bp) revealed identical breakpoints across multiple samples, albeit with a maximum of 3 samples sequenced per deletion [14].
Whereas microarray hybridization probes generate maximum signal with multiple deletions, aptamer sequences with the same deletion rate result in a 3-fold binding signal reduction compared with the same sequences synthesized for maximized sequence fidelity.
Accordingly, a deletion of this sequence produces a constitutively activated receptor mutant.
In addition, a large sequence deletion was evident.
The combination of the binding-site-sequence deletion and deletion of MPT5 results in both derepression of Ste7 protein levels and maximum Ste7 phosphorylation (Fig. 4A).
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