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Formation of the depropyl metabolite was slow with maximum concentrations attained at least 30 h after dosing (Fig. 2, Table 3).
The relationship between drug exposure and development of NVP HSR is unclear, but previous studies have reported higher plasma drug exposures in black African and Thai patients (4) and higher rates of liver toxicity in patients receiving once-daily NVP than in those receiving twice-daily NVP, presumably due to higher maximum concentrations attained after dosing (5).
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The mean maximum fluoride concentration attained during the 4 hour observation period was 1.86 μmol/L at 3.0 h after application of DSF.
At the 7 l scale the implementation of base only or full pH control (NaOH and H3PO4 additions) significantly increased both the maximum growth rate and biomass concentrations attained compared to fermentations without pH control.
During the night, at 21 00 06:00 LT, stratification in the atmosphere confined the vertical mixing, thus allowing radon trapping, which eventually caused PG reduction by favoring negative space charge formation (Latha 2007), while CO2 concentrations attained their maximum owing to respiration and lack of photosynthesis.
For gemcitabine, maximum concentrations were generally attained at 0.5 h post dose (i.e. at the end of infusion).
Plasma EPO concentrations attain a maximum between 6 12 hours after drug administration.
The relationships were not suitable for fitting to real data, because the maximum concentration was always attained by the chemical with equal affinities for both core and aqueous phases, i.e., having the core/water partition coefficient P = 1.
Additionally, between the two BPMs, RPSu-PVP-based BPM took less time to attain maximum concentrations for both acid and base when compared to PSDVB-based BPM.
Electrochemical stability increases with increase in nanofiller concentration attaining a maximum value of 5.8 V at 7.5 wt.
Beyond this value, the percentage inhibition appeared to approach plateau with the increment in the extract's concentration attaining a maximum percent inhibition of 48.3% with corresponding IC50 of 258.90).
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