The approved additives and their maximum amounts or maximum concentrations are listed in appendices II and III of the regulation.
These maximum concentrations are recorded during the spring and summer, when juvenile fish development is very sensitive even to low concentrations of ammonia.
Among the cations, the minimum concentration of Na, Ca, Mg and K are 16, 11, 10 and 5 mg/l and the maximum concentrations are 6,500, 1,872, 1,838 and 310 mg/l respectively.
Among the cations, the minimum concentrations of Na, Ca, Mg and K are 91, 48, 12 and 11 mg/l and 93, 48, 17 and 11 mg/l during the post- and pre-monsoon period and the maximum concentrations are 371, 212, 70 and 43 mg/l and 382, 204, 77 and 43 mg/l, respectively, during the post- and pre-monsoon periods.
It is important to note that maximum concentrations are established for each component of a product during the authorization process, while the actual concentration of a component in a marketed product may be lower (in case of the a.s., within a regulatory accepted range that ensures sufficient efficacy).
In contrast, in the STEC-HUS group the initial concentrations are lower but the maximum concentrations are much higher (∼1000 6000 ng/mL) in comparison with the non-HUS STEC group (∼2000 4000 ng/mL).
The maximum concentrations were reached 24 h after dosing in the majority of the animals (six of eight cats).
The maximum concentrations were found in the bottom layer (10 m; 670 μM).
Whereas the plasma concentration appears a bit lower for cTA12 than the mouse mAb during the first day after injection, the maximum concentrations were quite close.
Maximum concentrations were about four times the annual average.
The list of selected variables with their minimum and maximum concentrations was given in Table 1.
