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Exact(5)
maximum concentration within the dosing interval.
Firstly, a small number of patients who absorbed the compound more quickly, reaching maximum concentration within an hour.
M, male; F, female; Cmax, maximum concentration within the dosing interval; Tmax, time to reach maximum concentration; Cmin, minimum concentration within dosing interval.
The maximum concentration within tumours, using the CT-based quantitative method, ranged from 0.5 kBq ml−1 to 7.8 kBq ml−1, with a mean of 3.2 kBq ml−1, with corresponding SUVmax values ranging from 0.4 to 4.6, with a mean of 2.0.
Nonetheless, the total CM amount filtered by each nephron remains the same regardless of the tubular flow rate (assuming that the Saline salt and water are excreted at the same rate as infused, the urine flow will be 1 mL/kg/hr × 80 kg/60 min/hr plus 0.69 mL/min or 2.03 mL/min. The maximum concentration within the tubules is then 100/2.03 or 49 times the serum CM concentration).
Similar(55)
Overall, the results from the model show simulated time-averaged arc maximum concentrations within a factor of two of the observed data.
The time concentration profiles of MSF in rat blood showed maximum concentrations within 20 to 40 min after application.
In addition, the same authors demonstrated that valdecoxib produced maximum concentrations within the cerebrospinal fluid at 2 hours after administration, which lasted unchanged for another 6 hours.
Arterial washout of desflurane was more rapid; arterial concentrations fell to 18% of the maximum concentration reached within 4 minutes, and only 8% of the maximum arterial concentration was present in blood 20 minutes later.
The maximum concentration value within each tumour volume was recorded and used to generate SUVmax values using Eq. (1), which were compared with patient survival (in terms of months from the initial SPECT study) and analysed via linear regression.
What was also evident in the study was the slight difference in the time to maximum concentration (Cmax) within the eggs, with the 90 mg/kg group reaching Cmax at 24 h post-drug withdrawal and the 30 and 60 mg/kg dose reaching Cmax at 48 h.
Related(20)
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