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A computer-controlled syringe pump (402 Dilutor Dispenser; Gilson S.A, Villiers-le-Bel, France) allowed the simulation of drug concentrations by infusion of the drug into the central compartment until the maximum concentration achieved in serum (Cmax) was reached.
† Maximum concentration achieved at the beginning of the IPC treatment.
The mean maximum concentration achieved was higher than that on day 1 (134–536 ng ml−1).
The rate of absorption is indicated by the time taken to reach maximum concentration in the blood [ 17], the maximum concentration achieved after a dose of substrate reflects both of these factors.
The maximum concentration achieved in SSSF3 (11.6% v/v) was not optimal and there is room for further improvement by controlling substrate addition rates, initial enzyme concentrations and addition regimes, yeast strains (including high-temperature tolerant yeasts (Shahsavarani et al., 2013), and yeast nutrients.
For other antibiotics (where concentrations achieved with current regimens remain on the steep part of the concentration-effect relationship), it is the maximum concentration achieved (Cmax) or the related area under the plasma concentration-time curve (AUC) that is the best correlate of bacterial killing (Fig. 4).
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E7080 was absorbed rapidly with maximum concentrations achieved within 3 h.
The plasma concentrations of CYT997 at steady state (Css, Table 3) were the maximum concentrations achieved during the infusions.
Previous work [16], together with the results presented here indicates that the maximum ATP production rate is determined by the maximum mitochondrial concentration achieved at physiological conditions.
The pharmacokinetic parameters of Cmax (maximum plasma concentration achieved) and Tmax (time taken to achieve the maximum concentration) were determined by visual inspection of the data.
Bergapten was rapidly absorbed by rats with the maximum plasma concentration achieved within 3 h after dosing (5 mg kg−1) as seen in Table 1.
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