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For each permutation map, the clusters are recomputed and the maximum cluster statistic is recorded.
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Then, we compared the cluster statistics of each cluster with the maximum cluster statistics of 1000 random permutations and obtained a nonparametric P-value (P cluster).
This comparison resulted in a p-value, which was determined by the proportion of permutations in which the maximum cluster-level test statistic exceeded the actually observed maximum cluster-level test statistic in the data.
These plots again do not suggest any systematic differences between the two groups, and the permutation test yields a p value of 0.37 for the maximum cluster (however, we note that the t statistic is positive for 90.2% of all frequency pairs between 2 and 80 Hz).
We also conducted sensitivity analyses of the scan statistic results by setting the maximum cluster size to 10% and 5% of the population at risk, respectively.
Using the spatial scan statistic with elliptic clusters and a maximum cluster size of 10% of the population at risk identified two areas with higher prevalence of BCV than expected: Skaraborg (central-south part of Sweden) and Skåne (extreme south), as well as one area with lower prevalence than expected: Kronoberg-Blekinge (south-east of Sweden; Figure 3a).
The maximum cluster-level test statistic was then compared to a reference distribution of maximum cluster t-value sums obtained by randomly interchanging the labels of the baseline and activation period and recalculating the cluster-level test statistic 1000 times.
In addition, to examine the spatial distribution of subjects, we also performed a cluster analysis with a Bernoulli model, applying spatial scan statistic with 999 Monte Carlo replications and 50% of the total study population as maximum cluster size [SatScan Software,15].
where is the maximum cluster radius, and.
Table 4 Global statistics of the top 250 clusters Statistic Average Median Maximum Number of emails 38 28 376 Number of from 13.9 9 181 Number of replies 6.2 5 56 Number of subjects 9.9 7 114 Number of phones 2.5 2 34 Duration (in days) 396 340 1,454 Number of dates (distinct) 27.9 22 259 Compactness 2.5 2.5 5.0.
> -wrap-foot> Bapproximateate Brodmann's area; Hem, hemisphere; L, left; R, right; MNI, coordinates referring to the Montreal Neurological Institute template brain included in the SPM5 software package; tmax, maximum t statistic in the cluster; k, cluster size in voxels.
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