Sentence examples for maximum clinical dose from inspiring English sources
Two out of 10 monkeys who received 15 times the maximum clinical dose of E26, the next generation drug, died.
The monkeys that developed low platelet levels, a condition that can lead to uncontrolled bleeding, received 3 to 27 times the maximum clinical dose.
Although effective, the dose used in that study (about 100 times the recommended maximum clinical dose, as set out in the official label text) seemed impractical if statins were to have any use in bone formation in a clinical situation.
Thus, unlike cell death induced by other high-dose DNA damage stresses, which induce ROS-dependent cell death, it was suggested that gliomas do not produce ROS even after a maximum clinical dose of CB irradiation, which may be related to the refractory nature against standard radiotherapy.
The maximum daily clinical dose of TRK-100STP has doubled those of the immediate-release tablet for the indication of pulmonary hypertension in Japan.
Future studies should consider that a period of chronic dosing may be required before seeing maximum clinical effect.
PDTC (250 mg kg−1 ) was the maximum tolerated as a single dose in previous experiments utilising the BDF1 mouse (Bach et al, 2000), whereas 200 mg kg−1 NAC approximates to the clinical dose used in humans (Prescott et al, 1989).
In addition to establishing safety and the maximum tolerated dose, first-in-human clinical trials should be designed to demonstrate target modulation, define the proposed mechanism of action, and evaluate pharmacokinetic-pharmacodynamic relationships of a new anti-cancer agent.
Phase I studies are designed primarily to identify the maximum tolerated dose (MTD) for further clinical development of new drugs, and to evaluate their tolerability and toxicity profile.
Likewise, the maximum tolerated dose of FK866 in clinical trials yielded a 14 nM steady state plasma concentration, which is in the effective synergy range for combination treatment with β-lap.
Pre-therapy dose planning, as done in clinical studies, could maybe replace the maximum tolerated dose or the maximum tolerated activity studies in pre-clinical therapy studies.
