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Personalized treatment strategies could help to achieve maximum clinical benefit while avoiding excessive bleeding complications.
Neuromodulation offers the possibility to adapt parameters to avoid undesired consequences and to obtain the maximum clinical benefit.
The clinical application of these therapeutic strategies warrants further studies to ensure maximum clinical benefit in cancer patients.
RTOG S0132 has a similar design, though patients are treated to maximum clinical benefit prior to surgical resection.
Therefore, it becomes apparent that any gene therapy approaches for DMD should target early stages in muscle development to attain a maximum clinical benefit.
However, experienced shoulder surgeons in our unit believe that a minimum of 5-point improvement in OSS and 10-point improvement in CS would provide maximum clinical benefit.
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The current analysis incorporates an extended number of HPV-related disease endpoints including subtypes of head and neck cancer and as such reflect the potential maximum clinical benefits that could be gained from different HPV vaccination scenarios (in comparison with a number of previous analyses that have focused largely on cervical cancer and genital warts only).
Future research should attempt to elucidate uncertainties concerning the optimal roles of capecitabine and/or oxaliplatin in the adjuvant setting in order to achieve the maximum level of clinical benefit.
Therefore, healthcare providers and policy makers must consider PGx test sensitivity in their patient population in order to achieve the maximum clinical and economic benefits of pharmacogenetic stratification, even at higher costs of genetic testing.
This phase I/IIA study evaluated the maximum-tolerated dose (MTD), safety, and clinical benefit of pomalidomide, an immunomodulatory drug (IMiD), combined with cisplatin+etoposide chemotherapy, in treatment-naive patients with extensive-stage (ES) small-cell lung cancer (SCLC).
This pulsatile maximum tolerated dose (MTD -driven geMTD -drivenegemcitabineficantly impregimenlinical benefit resignificantlyly provimprovesest survival benefits (Burris et al, 1997).
More suggestions(15)
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