Sentence examples for maximum cell kill from inspiring English sources

Maximum cell kill is best achieved by using the optimal (not necessarily the maximum tolerated) dose level as often as feasible considering the impact of the drug on host toxicity.

As observed in the TSP, the majority of the TSQ cells were sensitive to the effects of doxorubicin and cisplatin with a maximum cell kill of 81±10 and 80±12%, respectively.

The authors of one study concluded that a treatment duration of 24 hours, giving a 5-AZA-CdR plasma level of around 2 μM, would be most desirable for maximum cell kill [ 117].

The negative controls ensure that siRNA transfection has no deleterious effects on cell growth while the positive control provides a reference of maximum cell killing possible and ensures transfection efficiency.

To account for tumour cell death induced by the cytotoxic drug, we assume that the drug kills proliferating cells in a concentration-dependent manner [ 22] and that the maximum rate of cell kill is equal to the rate of proliferation (a similar assumption for the action of a cytotoxic drug was used in [ 23]).

The extent of cell kill at the maximum drug concentration was high for all of the drugs (>85% see Table 1), demonstrating that the majority of cells within the TSP were drug-sensitive.

Maximal antiangiogenic activity typically requires prolonged exposure to low drug concentrations, exactly counter to maximum tolerated doses administered when optimal tumor cell kill is the goal.

When lowering the extracellular pH from 7.4 to 6.5, tunable functionalized vesicles deliver doxorubicin to cancer cells that increases from 41% to 93% of maximum resulting in cancer cell killing that increases from 23 to 71% of maximum, respectively.

Therefore, in contrast to the clonogenic cell kill resulting from bortezomib treatment, MG132-induced kill was not mediated by ROS.

In consequence, once tumor cells are arrested and synchronized they can be targeted with a cytotoxic agent, thus maximizing cell kill fraction and minimizing normal cell killing.

Atrophy (tissue shrinkage) reflects cell kill.