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Maximum body temperature recorded was significantly higher with oral solution misoprostol than with oral tablet, rectal and vaginal misoprostol (P=0.005, 0.009, 0.001, respectively).
In times of ample supply, oryx can use fluid loss through urination and feces to lower their body temperature to below 97 F at night, giving more time before reaching maximum body temperature the following day.
One day after challenge the maximum body temperature was observed; for each ferret the maximum body temperature is depicted in figure 1C.
Patient maximum body temperature per day did not differ significantly between both treatment groups (ITT population; data not shown).
Maximum body temperatures were observed during day one and these values were subsequently used for calculating the mean maximum body temperature for each group.
For analysis of CRP levels and daily maximum body temperature the multivariate repeated measures analysis of variance was done as described previously [21].
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There was no effect of CPS on the basal, minimum or maximum core body temperature of offspring in 12L:12D or during constant darkness.
The highest value of these measurements was presented as maximum core body temperature.
Minimum and maximum core body temperature measurements over the same time period were also assessed.
Maximum core body temperature over the 12 h after the morning dose for each subject was assessed on each measurement day and for each treatment.
However the differences from placebo in mean maximum core body temperature (Table 4) following XEN-D0501 on day 1 were 0.22°C (1 mg twice daily), 0.50°C (2.5 mg twice daily) and 0.74°C (5 mg twice daily).
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