Sentence examples for maximum blood concentrations from inspiring English sources

Pegram et al. (2002) reported maximum blood concentrations of CHBrCl2 ranging from 0.4 to 4 ng/mL due to ingestion versus 39 170 ng/mL due to dermal contact with water containing the same concentration of CHBrCl2.

Pharmacokinetic studies have shown that nicotine mouth spray delivers blood nicotine levels comparable to that of other NRT formulations of the same strength, 5 but that the mouth spray reaches maximum blood concentrations in approximately 10 min, which is significantly faster than the other oral NRT formats.

Specifically, JQ1 is reported to have a maximum blood concentration of 0.84 μM in mouse models, whereas the compounds I-BET-762 and I-BET-151 reach maximum blood concentrations of 26 μM and 82 μM, respectively (Dawson et al., 2011).

maximum blood concentration.

The time to maximum blood concentration is 2 h for oral naratriptan, and 1.5 h for oral sumatriptan [2, 4].

Extended-release formulations may reduce toxicity with a lower maximum blood concentration (Cmax) and improve efficacy with a higher minimum blood concentration (Cmin).

The observed maximum blood concentration (C max) and the half-life time (T 1/2) were obtained by visual inspection of the experimental data.

The study measures included Cmax (maximum blood concentration), AUC (area under the blood CyA concentration versus time curve, 0 to 4 hours) and actual time concentrations at individual sampling times.

There were no statistical differences between the novel SR pellets and the recently marketed SR capsule (Advagraf®, Astellas Pharma, Japan) in terms of maximum blood concentration, area under the curve, and half-life values, in both fasted and fed states.

The following PK parameters were calculated: area under the curve (AUC), mean residence time (MRT), total body clearance (CLtot), steady-state volume of distribution (V ss), elimination rate constant (K el), biological half-life (T 1/2), maximum drug concentration time (T max), and maximum blood concentration (C max) using standard procedures.

The PK parameters, such as the maximum blood concentration (Cmax), time to reach the peak blood concentration (Tmax), mean residence time (MRT), area under the curve (AUC0 t) and terminal elimination half-life (T1/2) were significantly (p < 0.05) different following transdermal administration compared with oral administration.