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For instance, Anxiety in our sample was above 7.3, that is the maximum average score found in the literature [ 13].
Extremely irritating (>80.0‐110.0) NOTE: The rating of the test substance is not to be increased more than one level above its maximum average score.
The primary end point shows that GI symptom intensities are significantly higher with every mixture compared with the control dessert with 35 g dextrose in the ITT (P<0.0001, Table 2) and PP (P<0.0001, Supplementary Table 1) populations, but remains in a low range, as maximum average score is 10.8/40.
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An average irritation score for each scheduled observation was then determined, with a maximum average irritation score derived from the observation yielding the highest average irritation score.
For proteins identified multiple times during the three CAD runs, the minimum and maximum average TMHMM score from their matched fragments are shown in Figure S1, Supporting Information.
The maximum average irritation score, using the Draize grading scale [ 12], was 4.0 at the 1-hour observation point for all three animals tested (Table 2).
To measure variation in domain composition, one protein with maximum similarity to orthologs is selected for each gene, that is, the protein with maximum average Jaccard score of domain content [ 20, 21].
We varied the r parameter in QUBIC, a rank parameter to discretize up- or down-regulated genes, from one to three and selected two for the maximum average match score in this experiment.
The lunar dust was rated as minimally irritating based on the maximum average irritation score, which is equivalent to "Not Classified (NC) for eye irritation" under the Globally Harmonized Classification system (UN-GHS) [ 13].
The maximum average irritation score was used to rate the test substance according to the definitions presented in Appendix B. OECD guideline 405 recommends that sequential testing, including the use of validated in vitro tests of corrosion/irritation, should be conducted prior to in vivo testing [ 9].
We also evaluated the mean maximum and average score achieved by each animal from day 0 to day 40 after immunization.
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