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The maximum allowed injection flow rate is 6 ml/s.
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On day 63, 9 weeks after tumour injection, all untreated mice reached the maximum allowed tumour size of 2 cm.
Untreated mice xenografted with Kyse30 cells reached the maximum allowed tumour size of ∼2 cm on day 63, 9 weeks after tumour injection.
Untreated mice xenografted with VHL wild-type ACHN cells reached the maximum allowed tumour size of about 2 cm on day 42, 6 weeks after tumour injection.
As shown in Figure 3A, in untreated mice, the tumor reached the maximum allowed size (about 2 cc, on day 63, which was 9 weeks after the injection of tumor cells.
Only a maximum allowed volume of 150 ml was predefined by the study protocol; all additional parameters, including injection rate and volume, were to be determined by the investigators.
On day 56, 8 weeks after tumour injection, all untreated mice bearing JIMT-1 and KPL-4 tumours reached the maximum allowed tumour size of about 2 cm.
In control mice xenografted with VHL mutant 786-O cells, the maximum allowed tumour size of about 2 cm was reached on day 49, 7 weeks after tumour injection.
Put in the maximum allowed of £20,000.
The punishment was the maximum allowed.
Those fines were the maximum allowed by law.
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