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Subjects between age 21 and 55 (right handed) with a minimum alcohol consumption of a regular pattern of two binge drinking episodes per week, otherwise healthy (no maximum alcohol consumption limit, but no history of severe brain injury or brain related medical problems, no symptoms of psychosis during a diagnostic interview), were included.
James Bond's weekly alcohol intake is over four times the advisable maximum alcohol consumption for an adult male.
AUI Maximum alcohol consumption and DAS did not correlate at intake, nor did AUI Maximum and SCL-90 Depression.
The figure also shows that the degree of change was dependent on the baseline level of maximum alcohol consumption.
Table 1 lists the descriptive statistics obtained from the DAS, SCL-90 Depression scale and AUI Maximum alcohol consumption in grams.
Women with lower baseline level of depression and a decrease during the study exhibited the strongest decrease in maximum alcohol consumption.
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Maximum intensity of alcohol consumption was quantified as the maximum units of alcohol consumed in a single week.
Also, in 2007 the World Cancer Research Fund/American Institute for Cancer Research published recommendations on the maximum recommended daily alcohol consumption.
However, the mean maximum intensity of alcohol consumption for the affected group was significantly higher than for the unaffected group (54.43 U/week, SD = 104.21 versus 23.78 U/week, SD = 36.88, P < 0.001).
Although there was a trend towards a greater likelihood of conversion among LHON carriers who were heavy drinkers (≥75th percentile), both cumulative and maximum intensity of alcohol consumption did not reach statistical significance either as categorical or continuous variables (Tables 4 and 5).
Visual failure was the dependent response variable used in the model, with the following as independent variables: (i) age, (ii) gender, (iii) LHON mutation (m.11778G>A, m.3460G>A, m.14484T>C), (iv) cumulative consumption of tobacco and alcohol and (v) maximum intensity of tobacco and alcohol consumption.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com