Exact(2)
A total of 20% of participants had one adverse reaction, 13% two adverse reactions, 9% three adverse reactions, and one participant 31 (the maximum) adverse reactions (figure).
Overall, more patients experienced a maximum adverse event of grades 3 4 toxicity than grades 1 2 (11 vs. 6 patients).
Similar(58)
This is notably due to the differences in the spatial and temporal scales for the maximum tolerable adverse effects between the protection goal level and the different ERA testing levels (lab, semi-field and field).
If definitions for environmental damage or maximum tolerable adverse effects refer to EU-wide protected natural resources (e.g. the EU-wide population of a certain taxon), then the spatial and temporal scales refers to the whole EU population.
Only one patient had PS 3. Table 2 > -wrap-foot> shows the incidences of maximum grade adverse events occurring during any cycle in the whole group.
The maximum number of adverse event episodes was also calculated.
The maximum number of adverse effects reported by any one participant was four (participant L2E001 in the 'fake 3D' group, who reported fatigue, faintness and impaired balance and coordination).
The study design was a randomised phase III comparison of ACE with platinum/etoposide as first-line therapy for patients with SCLC and a maximum of two adverse prognostic factors.
Previously untreated patients with histologically or cytologically proven SCLC and a maximum of two adverse prognostic factors (extensive stage disease, PS ⩾2, raised LDH, serum sodium <130 μmol l−1, Alk Phos >1.25 ULN) were eligible.
Analogously, in the benefit-risk setting, we'll define an incremental health benefit of the experimental therapy compared to the control as INHB BR = (p E - p C ) - (q E - q C )/ δ where δ can be thought of as the maximum number of adverse events one is willing to incur for each subject that benefits.
This review recommended that until larger scale intervention trials are completed, a low GI diet should not replace the current dietary recommendations from government and health agencies, and that further research regarding the optimal time to start a low GI diet for maximum protection against adverse pregnancy outcomes is warranted.
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