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The maximum administered tyramine dose was used as the TYR PD30 estimate when the predicted TYR PD30 was at least 20% larger than the maximum dose.
We have demonstrated that a mathematically definable level of 131I-MIBG can be added to 90Y-DOTATOC by reducing the maximum administered activity of 90Y-DOTATOC by a calculated amount yielding in most cases a substantial increase in delivered tumor dose while remaining within specified dose limits for bone marrow and kidneys.
The maximum administered dose was 1750 mg b.i.d.
A maximum administered FDG activity may be imposed by national law.
MTD was not reached but the maximum administered dose (MAD) was 1,100 mg/m.
As such, maximum administered doses in early trials may well exceed the dose required for efficacy.
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The maximum volume administered per nostril is 100 μL; the maximum total dose is 4.8 mg diamorphine hydrochloride (three sprays of 1600 μg/actuation product).
Maximum activity administered to the animal is usually smaller than 185 MBq (5 mCi) as the peak NEC value is 170 MBq for the Focus 220 (250 to 750 keV and 6-ns timing).
The maximum dose administered in the ER was 14 g.
These doses represented the maximum doses administered during the later pharmacological studies.
Chronomodulated 5-FU clinical efficacy is maximum when administered in nocturnal hours with a concentration peak at 4 00 a.m.
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