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Spermine, a polyamine that activates CK2, induced the greatest effect on these activities, whereas constitutive secreted CK2 activity exhibited a maximum activation of 247% (Table 3).
Pioglitazone and rosiglitazone were less potent against PPARδ but had five times more activity than aleglitazar, with a maximum activation of >30-fold.
In comparison with HIF-1, which is activated over a wide range of oxygen concentrations of around 2%, maximum activation of the UPR requires exposure to more severe hypoxia (reviewed in [ 49]).
The doodling condition resulted in maximum activation of the medial prefrontal cortex compared to coloring and free drawing; however, differences between the drawing conditions were not statistically significant.
We have proposed that there is a regulation of the maximum activation of lymphocytes.
Thus, determinants of receptor specificity reside within the flexible N-terminal segments of FGF19, although other regions within FGF19 are essential for maximum activation of FGFR4.
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APC, activated protein C; EC50, Concentration inducing half-maximum activation of PAR-1; PAR-1, protease-activated receptor 1; PROWESS, Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis.
To examine the role of auto-regulation in protein dynamics, we vary s' ime2, the maximum rate of auto-regulation-dependent Ime2 synthesis, c 2, the constant measuring half-maximum activation of Ime2 synthesis through auto-regulation, or both.
The negative feedback can also be manipulated by varying c 1, the constant measuring half-maximum activation of Ime1 degradation by Ime2, or by varying d' ime1 and c 1 simultaneously.
These activators had comparable values of maximum activation to 3 with slightly lower AC50 values (Table 1).
Conversely, the FWHM-based image processing method by Cazzell et al. to determine the activation maps relied on the level of reconstructed maximum activation, so the activation patterns were more affected by the level of maximum activation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com