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The Strut-Adjusted Volume Implant (SAVI; Cianna Medical, Aliso Viejo, CA) is a multichannel single-entry brachytherapy device designed to allow dose modulation to minimize normal tissue dose while simultaneously maximizing target coverage.
In this chapter, we consider the transformation mechanism as a multiobjective problem where the goal is to find the best rules maximizing target model quality and minimizing rule complexity.
We use this criterion as the maximizing target when we do cross validation to fix parameters, for example, number of Gaussian process m and temporal step size d.
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Substitution or even masking of these Aβ histidine residues might provide a new therapeutic direction for minimizing neuronal uptake and subsequent neuronal degeneration and maximizing targeting to amyloid plaques.
The loading regime was chosen to maximize target mRNA expression as reported in previous research.
To maximize target coverage, equal amounts of total RNA (10 µg) from three independent RNA extractions were pooled for RNA-Seq library construction at each time point.
Cut sections were trimmed to maximize target cell content (>70%).
The resulting increase in Zap1 protein level may maximize target gene expression and is also likely to be responsible for repression of ZRT2 under these conditions [ 17].
In order to maximize target coverage, equal amounts of total RNA from three biological replicates of each strain were pooled for RNA-seq library construction.
This facilitates bidirectional sequencing of both the sense and antisense template strands during one paired-end read, which maximizes target coverage.
By this standard, cNPF1 and related molecules have potential as chemical biology tools, pending further work to maximize target affinity and cell penetration.
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