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Compared with our previous work ([32]), the essential difficulty caused by the presence of singularity is how to analyse the asymptotic behavior of certain maximizing sequence near the blow-up point.
Then, the following alternative holds: either T has a fixed point, or, for each sphere S centered at 0, the restriction to S of the functional x → ∫ 0 1 〈 T ( s x ), x 〉 d s has a unique global maximum towards which each maximizing sequence in S converges.
The logic of building an alignment is partially circular: alignments are built in part by maximizing sequence conservation, but then are used to find conserved positions which are, in turn, identified as important.
Note that the order of contigs in assemblies was determined by maximizing sequence colinearity with the reference genomes.
A subset of 472 SNPs was chosen for further analysis by maximizing sequence coverage of 1 SNP per contig.
Sequence capture, which utilizes probes to enrich target sequences (e.g. Bi et al. 2013) (Box 1), offers a compromise between minimizing sequencing costs and maximizing sequence information from target regions of the study organism.
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Rather than maximizing sequences per species, we concentrated on increasing taxon sampling to minimise potential branch lengths.
Many SCOP [5] domain definitions, outside the multi-domain proteins class, match our "by sequence" definitions, as SCOP tends to maximize sequence continuity of domains.
In the second, we invert the sequence of the loop region for 19 taxa, by removing and replacing one form of the inversion with the reverse complement of its sequence, to maximize sequence homology across the inversion region.
Ultimately, to maximize sequence coverage and successfully locate the putative apratoxin A biosynthetic gene cluster, it was necessary for us to use both MDA-generated genomic information and traditional library screening methods.
Discrepancies between individual ESTs were resolved to maximize sequence similarity to highly similar homologs.
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CEO of Professional Science Editing for Scientists @ prosciediting.com