A range of 1.95 32,000 pg/ml of recombinant human cytokines was used to establish standard curves and maximize sensitivity of the assay.
Affective symptoms, thought disorder, and perceptual disturbances are also recognized as part of Criterion B, and operationalizing these features would serve to maximize sensitivity of detection.
There are multiple ways in which investigators have identified SREs using administrative claims, ranging from approaches that maximized sensitivity of SRE measures to methods that aimed at higher specificity for specific SRE subtypes [ 11– 19] (Fig. 1).
This suggests that TF correction may be important in maximizing sensitivity to detection of early disease.
Our approach to analysis of microarray data is to try to maximize sensitivity for detection of differences between experimental groups, and accuracy of estimation of absolute methylation fraction is, if anything, secondary.
Optimum cutoffs for each biomarker were defined using the highest Youden index to discriminate in the best possible manner AD from non-AD subjects, thus maximizing sensitivity and specificity of the analyses based on ROC curve analyses.
In this situation, maximizing sensitivity would capture the majority of patients with true COPD but at the cost of a large number of false positives.
Although conservation has proven to be an extremely selective miRNA detection criterion [ 28], it conflicts with the aim to maximize sensitivity, because of the existence of species-specific miRNAs.
In the Review of Future Talk, we tested and refined sets of 'word groups' in order to maximize sensitivity and specificity of the electronic database searching.
Although this approach allows us to maximize sensitivity, the rate of erroneously reported variants (specificity) is modestly increased at coverage depths of ≤10x (Fig. 3B).
