They optimized relative timing and sequence of drug addition; over time, the first drug 'rewires' the signaling network, by moving cells within state-space, maximizing responses to subsequent drugs.
Psychiatrists should be involved with the care of patients with chronic pain as early as possible to maximize response to treatment and improvements in quality of life.
This is because response to selection equals the change in mean TBV from one generation to the next, so that maximizing the accuracy of estimated TBVs also maximizes response to selection.
To attempt to control inbreeding and maximize response to selection, Wray and Goddard [ 4] proposed a dynamic selection principle, which places a penalty on the co-ancestry of the selected animals.
In addition, global positioning systems technologies enable increasingly precise application of added nutrients and variable spacing of seed to maximize response to the micro-environment defined by soil type, topography, and other factors.
In a situation where two or more environments are equally important, it might be possible to establish a separate breeding program for each environment to maximize response to selection for uniformity in each environment [ 43].
We will apply the Dillman method [ 58] to maximize response to questionnaires at T1, T2 and T3: a personalized reminder/thank you note (postal or e-mail) at 2 weeks, followed by a re-mailing of the questionnaire to non-responders at 4 weeks, followed by a reminder to continued non-responders at 6 weeks and a phone call at 8 weeks.
In this article, we will review recent advances in delivery technology with a focus on devices designed to optimally maximize responses to antigen cargo.
If PROMs are to be used routinely to monitor outcomes in LTCs, further research is needed to maximize response rates, to ensure that the PROMs used are reliable, valid and sensitive enough to detect change and that the time frame for data collection is appropriate.
