Calculate log Λ using the quadratic approximation in (A.1) around the MAP, and go to step (A) with the other τ to maximize log Λ by the direct-search maximizing method such as the simplex method (e.g., Kowalik and Osborne, 1968; Murata, 1992).
In this work, we aimed at maximizing method reproducibility by automation of most of the sample preparation, extraction, data acquisition and, to some extent, lipid identification, and post-processing of the data.
The aim of the work was to find the best experimental conditions, using a USP apparatus 2 (paddle), for maximizing the method precision as degree of repeatability.
In this paper we consider an expectation-maximization method for maximizing the likelihood of (time nonhomogeneous) evolutionary Markov models on trees.
Using the remaining portions of the assemblies we determined an optimum quality threshold for each analysis at which the average sequence quality was maximized (see Methods, Figure 2).
For the Maximized method, the recovery of in-focus photons increases the maximized image SNR and is superior to both uniform illumination and HiLo method.
First, the Maximized method improves SNR and SBR metrics compared to the HiLo method, while contrast remains mainly unaffected; this is because in the Maximized method the signal and noise statistics are taken into account explicitly, and therefore the available photons are utilized more effectively.
There are actually several methods: maximizing a robustness criterion [6, Section 5.1.3], maximizing the detection score [1], or maximizing the error exponent [7].
Using Monte Carlo simulations, we compare different methods (maximizing Youden index, maximizing mutual information, and logistic regression) for their ability to determine optimum binary cut-off thresholds for a ratio-scaled diagnostic test variable.
We also address the unknown properties of the input data by determining experimental data properties that maximize our method's performance.
Aping the profit-maximizing methods of AQ Khan, Li has apparently moved into the even more lucrative business of developing and manufacturing his own high-tech missile parts.
