Should first-in-human trials be designed to maximize the prospect of therapeutic benefit for volunteers, prioritize avoidance of unintended harms, or aim for some happy medium between the two?
After clinical examination, each pregnant woman had a standardized set of laboratory investigations to maximize the prospect of positively identifying the pathogen(s) causing her fever and to study comorbidities.
When ethics and religion collide, nobody wins; when religion and ethics find room for robust discussion and agreement, we maximize the prospects for constructive choices in our society.
As genome sequencing becomes more versatile and easier, the journal prioritizes those genomic sequences that maximize the prospects of harnessing genome variation and understanding evolutionary processes.
A gradual and ongoing removal of accommodation seems likely both to maximize the prospects of a continued expansion in the U.S. economy and to mitigate the risk of undesirable spillovers abroad.
The principal characteristics of the toxin molecule that account for its potency are its ability: a) to be absorbed from the gut with minimal degradation; b) to bind to receptors that maximize the prospects of a pathophysiologic outcome; c) to act by a multiplicative (viz., enzymatic) mechanism; and d) to modify a substrate that is essential for neuronal function.
Another source of doubt is the thought that the Rawlsian difference principle, the identification of distributive justice with maximizing the prospects of the very worst off (subject to the FEO constraint), is too extreme in the priority it assigns to achieving gains for the very worst off.
For example, the Medical Research Council (MRC) Good Research Practice policy articulates an economic mission and stipulates that MRC-funded researchers are expected to maximize the prospects of research being taken into practice through the commercial route by protecting IP rights [ 23].
He also has maximized the commercial prospects for his pet projects by committing them to film.
This format maximizes the potential for use across different software packages, as well as prospects for long-term preservation.
The first approach maximizes the choices available.
