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From the four different permutations, we selected the one with the confidence score that maximized specificity and sensitivity to compare it with the other taxonomic classification methods (Additional file 6: Figure S4A).
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The SNP site was employed to design inner primers but with a deliberate mismatch introduced at the 3′ antepenultimate from the mutation site in order to maximize specificity and detection efficiency.
Combinations of different markers were examined to maximize specificity and sensitivity.
Probe set design was carried out to maximize specificity and minimize cross-hybridization.
Visual inspection of the ROC curve suggested that no single part of the curve maximizes specificity and sensitivity [ 38].
Optimal hybridization conditions under which there was no appreciable cross-hybridization with the control spots were ascertained to maximize specificity and sensitivity.
Separation of this region was specifically chosen to maximize specificity at the expense of sensitivity.
However, maximizing specificity improved both precision (5.3% absolute increase) and accuracy (33.2% absolute increase).
We intentionally pursued a highly conservative analysis to maximize specificity.
Development of QMSP requires optimization to maximize analytical specificity and sensitivity for the detection of methylated alleles.
In addition to these keywords, we utilized the medical subject heading (MeSH) "shoulder fractures" combined with "fracture fixation, intramedullary" to maximize search specificity and sensitivity in the PubMed database.
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