The formulation optimization was performed using three factor two level full factorial design so as to minimize the particle size and zeta potential, maximize the entrapment efficiency as well as maximize the concentration of drug in brain with maximized brain/plasma ratio of the drug.
The test takes the ratio of the maximized value of the likelihood function for the full model (L1) over the maximized value of the likelihood function for the simpler model (L0).
Therefore, we assume that this novel design contributes to maximized efficacy, lower cost, a better risk-benefit ratio of treatment and more convincing results with strong application value and may be recommended for further clinical intervention trials.
The maximized value of propylene is 8.93 wt% at C/O ratio of 5.44 (gas oil mass flow rate is 51.8 kg/s and catalyst mass flow rate is 282.0 kg/s).
In general, the maximized value of propylene is 8.95 wt% achieved at C/O ratio of 5.45, even though, an average of 7.70 wt% of gasoline is lost due to secondary reaction with much coke deposited on the catalyst.
It could over-mask probes as well even though the masking signal intensity threshold determined the maximized number of commonly-selected genes in both species while maintaining a high correlation coefficient for the Nodule/Leaf ratio of commonly-selected genes between the two species.
The cells present on the outer layer of the distributed IOP-MC (O-IOP-MC) coating with a mass ratio of 0.67 revealed the most distinct osteogenic differentiation activity being promoted, which could be attributed to the maximized mechanical stimuli with exposure to SMF.
By applying the topology optimization method on the structure of the machine, a maximized stiffness weight ratio and homogeneous stiffness figures in the different directions are achieved, thus reaching the goals of the machine with a minimum mass.
Since it tries every possible path, the epidemic routing delivers messages with the minimum delivery delay and with the maximized delivery ratio.
Table 5 illustrated a summary of optimized molar ratios of Bi2O3 and TiO2 and also the related maximized alpha which obtained by canonical, graphical and numerical model optimization method.
