As we wished to determine a proof of principle (i.e., our methodology would be able to detect the effect of a maternal treatment on fetal vascular reactivity), we increased the dosage of SC to maximize the chances of seeing altered abdominal aorta arterial function; SC dosage was increased to 0.8 mg/ml SC in drinking water using the same E12.5 to E18.5 dosing regimen, as previously observed (6).
When using the oral route, patients should be advised that swallowing ROOs before complete dissolution should be avoided, to maximize the bioavailability and not to increase the dosage for a satisfactory analgesic effect.
However, in order to maximize the benefits of biochar addition, farmers need to accept that the dosage rates of mineral fertilizers should be reduced.
Last but not least, an optimized dosage was sought in order to maximize the percentage of porosity while achieving the lowest thermal conductivity.
To maximize the benefits offered by remifentanil, local analgesia/sedation protocols and dosage guidelines based on the dosing algorithm used in the present study will need to be developed.
The goal of dosage design for transdermal products is to maximize the flux through the skin into the systemic circulation and simultaneously minimize the retention and metabolism of the drug in the skin.
Less-frequently administered dosage regimens or nonoral routes may enhance compliance and so maximize the therapeutic benefit of bisphosphonates.
This strongly suggests the advantage of population modeling and dosage individualization using tools such as NPAG and the MM-USCPACK software to maximize the precision of achievement of target serum amikacin concentrations.
The effect of different dosages of H2O2 and KMnO4, pH and settling time was studied with an aim to maximize the reduction treatment efficiency and determining the optimum treatment conditions.
How do you maximize the investment?
In order to maximize the effect of β-lactam antibiotics, it may therefore be necessary to increase the fT>MIC to 100% or even maintaining the concentration four to five times the MIC for the entire dosage duration [ 28- 30].
