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Overall, it is crucial to identify an optimal DAR value with a controlled distribution for each ADC that can maximize the balance of efficacy, tolerability, and cytotoxicity profiles.
One answer that might be offered would be that some form of consequentialism is true such as, for example, the view that an action that fails to maximize the balance of good states of affairs over bad states of affairs is morally wrong.
The propensity score presented in the paper allowed us to maximize the balance covariates between the two studies.
(1) The lengths of barcodes were different form 5 to 9 bp to maximize the balance of bases at each position, especially in the BsaXI recognition sites.
In order to maximize the balance between stringency and sensitivity, we selected the peak of this curve (similarity level = 50%) as the optimum threshold for indel extraction.
To maximize the balance between tissue morphology and RNA quality, the sections on the slides should be immediately fixed with 100% ethanol at -25°C in the cryostat for 10 minutes, and then stored at -80°C for 2 hours.
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This approach uses an evolutionary search algorithm (i.e. a genetic algorithm) that chooses a weighting matrix W that maximizes the balance of the observed covariates across the treatment and comparison groups in the context of single nearest neighbor matching with replacement, by minimizing the following criterion.
The Youden index, which maximizes the balance of sensitivity and specificity, was used to calculate threshold values [ 44].
Rather, the optimal strategy should be to metamorphose at a rate that maximizes the balance between the probability of surviving metamorphosis and later fitness costs.
We used genetic matching, a generalization of propensity score and Mahalanobis distance that maximizes the balance of observed covariates between treated and control groups [ 18].
Thus, the optimum methanol concentration is a compromise between minimizing lipase deactivation and maximizing the equilibrium balance towards FAME synthesis.
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