After each modification, the quality of the rule is tested (to maximize both significance and predictive accuracy) and a size-limited set of the best rules is retained.
In addition, a feasible size of 96 samples is recommended for clustering to maximize statistical significance.
For each treatment regime, mouse-to-mouse transmission was performed in duplicate (except primaquine, where individual doses were tested in single experiments) to maximize statistical significance in balance with cost, with general parasite maintenance carried out as previously described (28).
The genetic algorithm consists of specially defined operators (e.g., crossover, mutation) that modify the initial rules, and thus the result are models that have "evolved" – after each modification, the quality of the rule is tested (to maximize both significance and predictive accuracy) and a size-limited set of best rules is retained.
It is a non-trivial task to trade-off between maximizing accumulate significance of the selected landmark set (mathbb {L}) and minimizing the size of (mathbb {L}), while guarantees the restriction that (mathbb {L}) must be discriminative to (bar{mathbb {R}}).
We selected the set based on the reliability, biological interpretation, and maximized statistical significance given the current data.
These combinations of onset and duration minimize the risk of loss of the developing rats while maximizing the significance of relevant symptoms they express as adults compared to controls.
At this point, it would be hard to say which part of the Administration's argument — attempting to minimize drilling's environmental impact or to maximize its strategic significance — is more misleading.
We determined cutoffs for the continuous variables of maternal age at birth and preceding birth interval to indicate early childbearing and short intervals, respectively, so that we could maintain a sufficient sample size for analysis and maximize the statistical significance of the model, while retaining consistency with the original purpose of the variable.
The phylogenetic analysis was done using the neighbor-joining method and 1000 bootstrap replicates were employed in each analysis to maximize the statistical significance [ 20].
