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As the cell strives to maximize its growth, it fully utilizes its resources and distributes them optimally to synthesize the essential cellular components.
The question how a population can maximize its growth in a changing environment is a classic problem in microbiology.
In this work, growth efficiency concerns the ability of a cell population to maximize its growth performance in a batch culture given an initial limited amount of resources.
In this paper we have verified the model ability to predict the cells behavior in different conditions without introducing measurements, experimental parameters, or any additional constraint, just by assuming that cells will make the best use of the available resources to maximize its growth.
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Please recall that the main goal of this paper is to evaluate the validity of the second model, i.e., the validity of assuming that P. pastoris cells objective is maximizing its growth rate.
Instead, each different cell is assumed to maximize its individual growth.
While the assumption that each species attempts to maximize its own growth rate is most common, other community objectives that capture more complex behavior such as altruism can be employed [ 34].
The key underlying assumptions used in FBA are: (i) cellular metabolism operates at a steady state for a given environmental condition, wherein the concentrations of all internal metabolites and rates of all reactions are constant; (ii) the organism can adjust its metabolic fluxes -- rates at which individual reactions convert substrates into products -- to maximize its biomass growth flux.
A preliminary version of the dynamic co-culture model was developed by directly combining the dynamic models of the two yeast species under the assumption that each species attempted to maximize its individual growth rate and the only interspecies interaction was competition for glucose substrate.
Mtb has become a formidable pathogen by utilizing whatever carbon it can acquire to maximize its potential for growth.
The existence of haploproficient genes in the yeast genome indicates that the organism has not evolved to maximize its rate of growth, even when sugars became abundantly available with the emergence of flowering plants approximately 80 100 million years ago [ 11].
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