Successful translation of pluripotent stem cell technology is contingent upon maximizing efficacy of lineage-specification and minimizing risk of dysregulated oncogenic growth.
CAM-ICU: confusion assessment method for the intensive care unit; ICU: intensive care unit; MENDS: maximizing efficacy of targeted sedation and reducing neurological dysfunction; RASS: Richmond Agitation-Sedation Scale.
In a subgroup of 39 septic patients from the MENDS (maximizing efficacy of targeted sedation and reducing neurological dysfunction) trial, the risk of dying was lower in the group that received dexmedetomidine compared with lorazepam (hazard ratio = 0.3, 95% confidence interval = 0.1 to 0.9, P = 0.036) [ 14].
As reported in the previous issue of Critical Care, Pandharipande and colleagues [ 1] use data from the MENDS (maximizing efficacy of targeted sedation and reducing neurological dysfunction) trial, which compared dexmedetomidine with lorazepam for ICU sedation in a randomized double-blinded fashion [ 7].
In practice, AEDs are titrated for each patient to maximize efficacy and tolerability of the drug.
The STAT-1 decoy ODN was injected intra-articularly four hours prior to arthritis induction to allow sufficient cellular uptake and maximize efficacy at the time of induction.
Therefore, the optimal time to initiate a new therapy after natalizumab discontinuation requires further investigation, and should also be considered on an individual patient basis to maximize efficacy and reduce risk of disease relapse and residual natalizumab effects.
We hypothesize that placing a sustained dexamethasone release system near back of the eye through a fine needle can maximize efficacy while mitigate higher rate of IOP rise and cataract.
Therefore, it is important to confirm tumour selectivity of a novel candidate mAb to minimize toxicity and maximize efficacy, preferably in early stages of drug development.
In line with this and also with Dalfino et al. [ 26, 27], our results suggest that the administration of higher daily CMS doses while prolonging the dosing interval (according to colistin's concentration-dependent pharmacokinetic behavior) could be a reasonable strategy to maximize efficacy without increasing the risk of nephrotoxicity.
