Aiming to maximize continental differentiation of haplogroup origins we additionally genotyped 18 additional SNPs among samples identified as belonging to haplogroup E (M33, P2, M2, M154, M191, M215, M35, M78, V12, M224, V32, V13, V22, M81, M123, M281, V6, and M75).
Therefore the 34plex assay comprised SNPs selected with ascertainment bias for maximizing the differentiation of these three major population groups and would not necessarily include the best SNPs for distinguishing Europeans from North Africans.
Taken together, these findings identify the optimal ratio between two major minerals in bone mimetic scaffolds to maximize the osteogenic differentiation of MSCs.
In fact, the ENIGMA working groups each aim to find heritable brain measures that maximize case control differentiation, for studies of disease.
The general idea is to identify genes (combination of them) that maximize the differentiation between N and PRE groups.
It will be essential to address the interactions between these various pathways to maximize cardiac differentiation from human ES cells.
The results demonstrate that FFF scaffolds with surface roughness can support hBMSC proliferation, while also inducing osteogenic differentiation, to maximize generation of calcified tissue.
Hypoxia plays a key role in this process by altering the response of progenitor cells to the other signals, which maximizes the expansion and differentiation of stress erythroid progenitors[3].
The results suggest that 570 μM and 60 μM are the optimal IKVAV concentrations for 2D and 3D neural differentiation, respectively, to maximize mRNA expression of neuron-specific markers and neurite extension while minimizing apoptotic activities in cultured cells compared to those exposed to higher IKVAV concentrations.
The method implemented in SAMOVA employs a simulated annealing procedure and uses allele frequency data along with geographic coordinates of the sampled populations to identify population groups maximizing genetic differentiation.
