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The extreme categories were created to maximize differences between groups.
Each canonical variate describes the multivariate linear combination of coloration variables that maximize differences between groups while minimizing differences within groups.
Although alkanes and aromatics are inert pollutants, we excluded alkane and aromatic pollutants from the inert classification to maximize differences between chemical property groups.
In addition, for the 'member' group only schools that have recently (< 3 months) joined K-GFYL will be sampled, in an attempt to recruit schools that are not well advanced with the implementation and therefore maximize differences between the groups.
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In addition, the benefit of our approach is that we provide data applicable to synovial samples from patients with different disease durations and different pharmacological treatments, which maximizes differences between patients [ 1], thus increasing the representativeness of our study.
Group-specific norms have, among other things, the twofold function of minimizing perceived differences among group members and maximizing differences between the group and outsiders.
For these experiments, 1% serum was selected as this maximizes differences between normoxic and hypoxic proliferation.
This appears to be secondary to including a smaller area over which to measure, which maximizes differences between measurements.
Ward's method minimizes distances within groups while maximizing differences between group and thus provides the best chance of identifying relevant clusters of items [ 25].
In the case of shape data, we chose to average the scores of the uncorrected and size-corrected shape PCAs run on individuals (see details above) instead of averaging the landmark coordinates by population first and then running PCAs on the averaged data to avoid maximizing differences between populations.
Each pixel of the CT images is attributed a colour which represents the numerical value of perfusion parameter calculated for that pixel and the colour scale is chosen by the operator in order to maximize the differences between areas having different perfusion.
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