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All of these considerations should be balanced against maximising the sample size to get a more reliable estimate of the treatment effect; examination of secondary end points (DeMets, 2006) and important, pre-specified subgroup analyses; and not missing an intervention with a moderate benefit, which is still clinically worthwhile.
Therefore, to strengthen our findings by expanding the study base and maximising the sample size, we conducted a nationwide study with prospectively collected, registry-based data to evaluate whether use of aspirin or other NSAIDs may reduce the risk of HL, and combined these results with those from the US study in a meta-analysis.
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Furthermore, we wanted to maximise the sample size and hence the power in our calculations of, especially, the genetic correlation in lifetime fitness across the sexes.
We also used multiple imputation to maximise the sample size available.
To maximise the sample size in the analyses, unconditional logistic regression was also performed.
However, both of the above measures were incorporated into the study design to maximise the sample size.
Assuming an exposure prevalence of 50% maximises the sample size necessary to detect a relative risk of this magnitude.
Using a self-completion questionnaire for most of the data collection maximises the sample size for a given budget, whilst retaining the original sample design.
20 The data sets used in this study were the 2003, 2008 and 2013 NDHS surveys, pooled together to maximise the sample sizes of deaths.
30 32 The serial cross-sectional analysis of four waves of ELSA included all eligible participants in each wave in order to maximise the sample size.
13 Prior to our analysis, we conducted mean imputation for missing data in order to maximise the sample size for analysis.
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