The Dutch ships had waited until the British were well within effective range in order to maximise the effect of their shot, and soon Onslow's flagship was under fire from the entire rearguard of the Dutch line, the ship suffering damage while attempting to break through the Dutch line between Jupiter and Haarlem at 12 30.
Combination therapy with gonadotropin-releasing hormone (GnRH) analogues, that is, goserelin acetate effectively reduces the excess substrate levels, and may therefore maximise the effect of aromatase inhibition, suggesting that such a combination may be more effective than AIs alone in metastatic male breast cancer patients (Giordano and Hortobagyi, 2006; Soon Wong et al, 2007; Onami et al, 2010).
Combination therapy with a gonadotrophin-releasing hormone agonist effectively reduces the excess substrate and maximises the effect of aromatase inhibition, and has been seen to cause regression in male patients with disease refractory to aromatase inhibition alone [ 49].
Singing generates endorphins and makes us happy, but what should we sing to maximise the effect?
If necessary, budgets should be skewed to maximise the effect of public expenditure in keeping the economy moving forward".
Discuss your feelings at the end of the day, to maximise the effect of any positive interaction.
"Placebos can maximise the effect of medication," says Robert Jütte, author of the study and a BÄK board member.
"To maximise the effect of pandemic policies, future efforts might need to combine vaccination programmes with support for the most effective non-pharmaceutical interventions".
They're delivered in increasingly tipsy style by the bibulous Irishman, who maximises the effect of his fine comic phrases (a nap-taker snoring sounds "like two bananas thrown into the Hadron collider") by seeming to hiccup them randomly into being.
