To maximise sample size, this subsample included respondents who reported seeking treatment (n = 324) as well as those who did not seek treatment (n = 303).
In order to maximise sample size and avoid bias, missing values were included for all covariates.
To maximise sample size, the multivariate analysis was confined to maternal predictor variables, since these were available for all families.
Our strategy was to maximise sample size by genotyping all available DNA samples rather than splitting the cohort into test and confirmatory data sets.
We created models by using a two step process to maximise sample size and power while restricting variables included at each stage of the analysis.
Kaplan Meier plots and survival analysis methods allow for whatever follow-up time is available for each person, thereby maximising our sample size and allowing statistically significant conclusions to be drawn.
All of these considerations should be balanced against maximising the sample size to get a more reliable estimate of the treatment effect; examination of secondary end points (DeMets, 2006) and important, pre-specified subgroup analyses; and not missing an intervention with a moderate benefit, which is still clinically worthwhile.
Therefore, to strengthen our findings by expanding the study base and maximising the sample size, we conducted a nationwide study with prospectively collected, registry-based data to evaluate whether use of aspirin or other NSAIDs may reduce the risk of HL, and combined these results with those from the US study in a meta-analysis.
Furthermore, we wanted to maximise the sample size and hence the power in our calculations of, especially, the genetic correlation in lifetime fitness across the sexes.
We also used multiple imputation to maximise the sample size available.
To maximise the sample size in the analyses, unconditional logistic regression was also performed.
