An understanding of how the clock influences expression of the drug target or elements of the drug's metabolic pathway can be utilised to optimise dosing times to make treatment more effective; this might maximise effectiveness and minimise side effects.
As factors were emphasised differently between networks, local flexibility in interventions is likely to maximise effectiveness.
We expected that ergonomics training, coupled with flexible workspace design, would maximise effectiveness for the workers.
To maximise effectiveness, the vaccine needs to be given to girls before they are sexually active [ 11].
The cost effectiveness of this method was also emphasised, however, further research is necessary to determine the intensity level of the intervention to maximise effectiveness.
Therefore, to maximise effectiveness, intervention designers are likely to benefit from drawing from a wider range of theories than currently used.
This included pooling of budgets [ 11] and outsourcing training/tuition [ 9]. 3. Effective use and outcomes Several publications highlighted the need for wheelchairs to be useable in all places required in order to maximise effectiveness [ 8, 12, 15].
More generally, the European Commission is seeking to achieve a 'European Research Area', whereby researchers, research commissioners and research users (the 'research triangle') coordinate their activities to maximise effectiveness and international competitiveness [ 38].
ADHC-WR aims to provide interdisciplinary therapy services to clients wherever possible, as best practice, to maximise effectiveness and to minimise overlaps/gaps [ 8], particularly as most ADHC-WR clients have multiple service needs [ 9].
11, 53– 55 An enhanced incentive scheme for alcohol brief intervention in England — such as a QOF indicator for unselected screening and brief intervention delivery — may maximise effectiveness and cost-effectiveness by being structured to encourage brief screening followed by simple feedback and written information.
