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To overcome this, we used an iterated procedure that selected a sign for each subject that maximised the correlation coefficient in the evoked response, between subjects, and then multiplied each subject's data by the appropriate sign.
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The classes are then ordered in a two-dimensional output space by maximising the correlation coefficient (r) between the Euclidean distances separating the classes in data space and their corresponding distances in output space.
Instead, the focus is on maximising the correlation between the steady-state pattern of the predicted fluxes and the corresponding gene expression data at the biochemical level.
An alternative objective function is presented, that is based upon maximising the correlation between experimentally measured absolute gene expression data and predicted internal reaction fluxes.
A threshold was applied to each ranked internal test set list of probabilities to find the optimum cut-off probability that maximised the Matthews Correlation Coefficient with respect to that test set.
The MCA generates quantitative scores, called dimensions, which are linear combinations of the dummy variables that maximise the average correlation between them.6 The first dimension of the MCA that takes into account the largest part of the observed heterogeneity reflects the intensity in use of the selected tools.
The number of latent variables, c, that maximised this correlation was used for each density.
Instead, an iterative process is used to assign the data to the model: 1. Maximise the correlation between the initial set of irreversible reactions and the experimental data.
More recently, and in the context of GWAS, Yang et al. [ 75] used an approach similar to ours to find the P-value that maximise the correlation between the proportion of significant SNPs and the heritability across 47 traits.
The ICE algorithm uses the expectation/mean instead of the mode of the posterior, because (1) the mean of g maximises the correlation between g and g ^ [ 2]; and (2) due to the spike at zero the posterior may be bi-modal (see Results), in which case the mode may be quite far away from the mean.
Toe and heel-walking and step ascending tasks maximised the number of parameters with a moderate-to-good correlation with patients' clinical status.
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