The main findings of our systematic review were that, on average across all studies, the optimum threshold (to maximise sensitivity and specificity) for protein to creatinine ratio to detect significant proteinuria is between 0.30 and 0.35, relating to sensitivity and specificity values above 75%.
Relatively large volumes of CSF are recommended to maximise sensitivity and provide sufficient material for completion of the various diagnostic tests.
To maximise sensitivity we used photographic film for detecting PrPSc however to estimate glycosylation ratios in each brain area densitometry could be carried out.
Based on Youden indices to maximise sensitivity and specificity, cutoffs were established for each of the prototypes and ultra short prototypes.
PD calibrations were adjusted at the lowest permissible pulse repetition frequency to maximise sensitivity and were taken as constant for the same joint in different patients (dependent on the investigated joint), with a pulse repetition frequency ranging from 0.5 to 0.75 MHz.
The aim was to maximise sensitivity, and minimise false positives and again, for comparison, ROC curves are presented [ 20].
However, the aim of this analysis was not to develop a screening tool for depression but to use ROC analysis as a method to maximise sensitivity and specificity in determining the optimal cut-off value for low blood pressure.
14 We evaluated strategies to maximise sensitivity while minimising false positives in a screening test for duct dependent circulation with a new generation oximeter which measured functional oxygen saturation preductally (in right hand) and postductally (in either foot).
As only a small amount of tissue is obtained from a murine brain, biochemical methods, in particular a western blotting technique for PrPSc had to be adapted to maximise sensitivity.
