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Some have proposed that continuous and extended infusions of time dependent antibiotics maximise efficacy by increasing the time in which serum concentration is maintained above the minimum inhibitory concentration therefore improving clinical outcomes.
However, within the constraints of drugs that are currently available, targeting IPT at the peak in transmission remains necessary to maximise efficacy in seasonal settings.
22 Other evidence stresses that a quetiapine dose ≥400 mg is required to maximise efficacy in acute psychosis or mania.
These findings are encouraging, considering the uncertainties regarding the optimal dose of colistin to maximise efficacy while avoiding toxicity.
As cell therapies mature, we will no doubt see new and innovative delivery approaches to try and maximise efficacy.
The combination of steroids and abiraterone acetate should potentially prevent the syndrome of secondary mineralocorticoid excess and maximise efficacy.
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Prior modelling using specialised software (spray drift AGDISP) enabled subsequent aerial applications to be undertaken with minimum drift, thus maximising efficacy for a successful eradication within a semi-rural environment.
The goal of targeted cancer therapies is to specifically block oncogenic signalling, thus maximising efficacy, while reducing side-effects to patients.
To identify the Doc and G-CSF combination schedule, which maximises efficacy and minimises neutropenia, our developed treatment optimisation method (Agur et al, 2006) was used.
In patients scheduled for local salvage EBRT after RP, accurate anatomic localisation of tumour deposits within the post-prostatectomy bed, by means of mp-MRI, may allow for an individualised field of irradiation, thereby maximising efficacy and minimising toxicity to normal surrounding tissues.
This research describes stages in the reproductive development of B. seriolae and Z. seriolae and discusses the inclusion of basic parasitic life-cycle parameters into management strategies designed to maximise treatment efficacy and limit monogenean epizootics in sea-cage kingfish culture.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com