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To evaluate insulin-induced changes in DAT-mediated DA uptake, the initial portion of the falling phase of evoked [DA]o curves was fitted to the Michaelis Menten equation to extract Vmax (maximal uptake rate constant)56.
We tested this hypothesis using a form of the MRGluc calculation that employs the Michaelis-Menten relationship to compute the hypothetical maximal uptake rate [MRGlucMAX] based on an empirical half-saturation K M of 130 mg/dL (see 'Results' section).
For simulations under the null hypothesis, the maximal uptake rate M R gluc max was set the same in the control and treatment groups, and we evaluated the effect on the false positive rate (i.e., concluding that there is a treatment effect when in fact there is none) caused merely by a change in mean blood glucose.
Questions remain to be elucidated as to whether there exists an optimal ligand density for maximal uptake rate.
The overall optimal range of ligand density indicates that the maximal uptake rate is achieved when nearly every ligand binds with a receptor.
Our model predicts that the optimal radius of NPs for maximal uptake rate falls in the range of 25 30 nm, and optimally several tens of ligands should be coated onto NPs.
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Given our setup, in the regression framework, the t-test of equality of the maximal uptake rates M R gluc max, C and M R gluc max, T is a likelihood ratio test and the uniformly most powerful unbiased test [34].
Recently, Mulugeta et al. (1997) showed that the maximal uptake rates (Vmax) of ISMM in resistant T. congolense were significantly lower than in sensitive populations.
The maximal uptake rates of fusion protein in liver, spleen and lung was achieved 13 h after injection, compared with 3 h for IL-1ra.
The standard value for maximal oxygen uptake rate Vmax was equal to a value reported for hepatocytes in a similar system (Nyberg et al., 1994).
Maximal basolateral uptake rate exceeds canalicular efflux due to a much larger surface area on the sinusoidal side of the cell.
More suggestions(15)
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