Sentence examples for maximal tolerated dose from inspiring English sources

In a phase 1 trial the maximal tolerated dose is determined based on clinician assessment of toxicity during the first cycle of treatment.

To identify the maximal tolerated dose level of preoperative intensity-modulated radiotherapy combined with capecitabine and oxaliplatin and to evaluate the efficacy.

At that point in time he was under chronic treatment with verapamil (maximal tolerated dose of 560 mg/day) for 6 months with only a mild effect on attack frequency.

The maximal tolerated dose was not reached.

The maximal tolerated dose was 1.2 mg m-2 day-1.

Maximal tolerated dose was determined to be 800 mg day−1 of vorinostat.

Maximal tolerated dose was at 68 mg m−2 dand1 andose-limitingng toxicities consisted of cumulative bladder toxicity.

In earlier experiments, this dose was found to be the ½ maximal tolerated dose in the mouse strain used and was well tolerated in repetitive dosing regimens.

In accordance with other studies, the dose 100 ng/kg was found ineffective and 500 ng/kg was established as the maximal tolerated dose.

One patient death from QTc prolongation was reported at the 34 mg m−2 per day, and the study was terminated without reaching the maximal tolerated dose level.

Rats bearing peritoneal CC531 tumours (2-6 mm) were treated i.p. with cDDP or CBDCA [maximal tolerated dose (MTD)] in combination with regional hyperthermia (41.5 degrees C, 1 h) of the peritoneal cavity.