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In 1978, Nossal and Pike experimentally demonstrated that bone marrow-derived cells cultured with an antigen became tolerant to the antigen in a time-dependent manner, with maximal tolerance being achieved only when the antigen was present continuously as the cultured bone marrow cells matured [18].
Co-expression of the two soluble flavoproteins in the chloroplast stroma resulted in lines displaying maximal tolerance to redox-cycling oxidants, lower damage and decreased ROS accumulation.
The results demonstrated that no-observed-adverse-effect level (NOAEL), lowest-observed-adverse-effect level (LOAEL), maximal tolerance dose (MTD), and minimal lethal dose (MLD) were respectively 5, 6, 30, 35 mg/kg for i.v. administration of dipfluzine hydrochloride.
So, the Maximal Tolerance Dose (MTD) method was adopted to evaluate the acute oral toxicity of the hydrogel.
Considering the experimental design of the screening carried out to search for genes required for maximal tolerance to acetic acid, it was not expected that the identification of ISA1307 HAA1 homologue would fail.
Haa1 is considered one of the key players in the control of S. cerevisiae response to acetic acid due to its role in the direct, or indirect, regulation of approximately 80%% of acetic acid-responsive genes [ 6], several of them required for maximal tolerance to acetic acid [ 8].
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Using the IBM, we determined for all three airborne behaviors the effect of maximal tolerances for drift angle (hereafter: drift tolerance) and transport cost (hereafter: transport cost tolerance) on the probability of successfully arriving at the Iberian coast (hereafter: arrival probability) and on migration speed (km d-1 including stopovers).
Typical search parameters for both search engines were defined as follows: trypsin digestion allowing up to two tryptic-mass cleavages, variable modifications of oxidation and carbamidomethyl, maximal mass tolerance of 0.1Da, precursor tolerance of 100 ppm, and taxonomy Homo sapiens.
Maximal exercise tolerance (VO2peak and RPmax) and submaximal exercise tolerance (VO2AT and 6MWT), FEV1 and FCV were correlated with eGFR (Table 4 and Figure 2).
In order to achieve maximal furfural tolerance it is probable that both increased furfural conversion and ROS tolerance will need to be considered in future strain development strategies.
Aim: To compare the effects on maximal exercise tolerance of 12 weeks of four dosages of telmisartan (10/20/40/80 mg once daily), an AT1 specific angiotensin II receptor antagonist, or continuation on the angiotensin converting enzyme inhibitor enalapril, in patients with stable, mild-to-moderate congestive heart failure (NYHA Class II and III and left ventricular ejection fraction ≤40%).
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