Sentence examples for maximal tolerable dose from inspiring English sources

When no statin is tolerated or the maximal tolerable dose of statins fails to reduce LDL cholesterol to target levels, nonstatin therapies should be used.

There are some important issues which should be studied in the future, such as the number of cycles, the maximal tolerable dose, and the quality of life of these patients.

The activities administered were based on an estimate of the maximal tolerable dose to bone marrow, using historical 177Lu-BR96 biodataribution data for the theoretical calculation of the absorbed dose resulting from treatment with 211At-BR96 [27].

IT BoNT-B 0.5 U was established as the maximal tolerable dose for experiments from this point forward.

Animals that received the maximal tolerable dose of BoNT-B showed normal motor coordination, grip strength and exploratory behavior on the wire mesh.

In order to assess weight loss, mice that received maximal tolerable dose of BoNT-B were weighed 7 days after intrathecal injection.

Secondly, it allows for the assessment of patient-specific bio-distribution and the calculation of organ doses which determine the maximum tolerable dose (Kairemo & Kangasmaki, 2013).

Phase I studies follow a dose-escalation regimen designed to determine the maximum tolerable dose (MTD).

The primary endpoints were the maximum tolerable dose and the safety.

In a review on the toxicity of α-emitting radionuclides, Dahle et al. [24] presented values for maximal tolerable doses to the bone marrow (MTDBM) ranging from 0.4 to 7.6 Gy for different α-emitters.

Carvedilol was titrated from 3.25 mg per day and metoprolol was titrated from 12.5 mg per day to maximal tolerable doses.