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Exact(1)
True determination of the maximal tissue concentration is questionable on this basis.
Similar(59)
Area under the curves and maximal tissue concentrations were similar for SP1049C and free doxorubicin in liver, kidney, heart, lung and plasma.
total non-displaceable tissue concentration.
This allows maximal tissue penetration, and, therefore, desired therapeutic results.
By dividing these predicted tissue concentrations by half maximal inhibitory concentrations values determined with embryonal rhabdomyosarcoma cells (3.99 µmol/l and 4890 µmol/l for simvastatin acid and pravastatin, respectively), an in vivo marker for statin toxicity was calculated.
As in the rat tissue experiments, maximal ethanol concentrations in the vehicle control were 0.5%%.
Moreover, moxifloxacin both intravenously and orally exhibts high penetration in lung tissue with maximal lung concentrations of 12.37 μg/g and 16.21 μg/g for iv and oral administration respectively (Breilh et al 2003).
Briefly, concentration response titration points for each compound were fitted to a four-parameter Hill equation (Hill 1910), yielding half maximal concentration (AC50) and maximal response (efficacy) values.
Half maximal lethal concentration.
half maximal inhibitory concentration.
half maximal effective concentration.
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