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The maximal suppression on intrinsic hepatic clearance of CYP2C9 was 17%, occurred at ∼70 hours, and lasted for ∼9 days.
The maximal suppression on intrinsic hepatic clearance of CYP3A4 was 28%, occurred at ∼48 hours, and lasted for ∼1 week.
Similarly, the maximal suppression on intrinsic hepatic clearance of CYP1A2 was 9%, occurred at ∼48 hours, and lasted for ∼1 week.
Simulations were also performed with the highest IL-6 profile; the projected maximal suppression on hepatic intrinsic clearance of CYP3A4, CYP1A2, and CYP2C9 was 20%, 19%, and 14%, respectively.
Similar(56)
Using this formula, the maximally-achievable score is 4.55 (maximal suppression of 128Q cytotoxicity, i.e. 100% responsiveness) and the minimally-achievable score is -1 (maximal aggravation of 128Q cytotoxicity).
Effects of the Acthar on IgM accumulation in culture supernatants were also observed with maximal suppression of 70.8 % at the highest concentration of Acthar (p <0.05; Fig. 1, bottom panel).
The highest UP pigment concentration increased lipid peroxidation and the incidence of micronuclei by more than 70% with maximal suppression of cell proliferation.
Androgen deprivation therapy (ADT), which involves the maximal suppression of circulating testosterone, underpins the treatment approach to metastatic hormone sensitive prostate cancer.
With 50 µM curcumin, maximal suppression of ACTH secretion was achieved.
For in vivo colonization experiments, we tested P2M5A-24 and P2M5A-26 cell lines as they had maximal suppression of STAT1 with 6- and 12-fold suppression, respectively, as measured by QRT-PCR (results not shown).
Suppression of lipolysis during an OGTT was assessed as FFAAUC adjusted for mean plasma insulin concentrations and percent maximal suppression of FFA levels.
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