No studies have investigated whether physical activity may reduce suPAR levels using a randomized controlled design.
Toldi G, Biro E, Szalay B, Stenczer B, Molvarec A, Rigo J et al. Soluble urokinase plasminogen activator receptor (suPAR) levels in healthy pregnancy and preeclampsia.
Serum SuPAR levels are elevated when TB is active and decrease when the patient responds positively to therapy.
Enrolled patients were stratified in different groups according to their APACHE II score (APACHE II > 18), PLT counts (PLT ≤ 128.000) and serum SUPAR levels (SUPAR > 8.1).
Studies in patients from emergency units have further indicated that suPAR levels also associate with disease prognosis.
Serum suPAR levels were measured using the suPARnostic enzyme-linked immunosorbent assay (ELISA) kit according to the instructions of the manufacturer (Virogates, Birkerød, Denmark).
In multivariate analysis, higher APACHE score, thrombocytopenia, and higher serum SUPAR levels were statistically significantly associated with a higher risk of ICU mortality.
SuPAR levels increased in time.
As shown in figure 2, patients with low suPAR (suPAR range 1.22 3.85 ng/ml) and those with median suPAR levels (suPAR range 3.86 5.88) progressed significantly slower to death compared with patients with high suPAR levels (suPAR range 5.94 12.16)(p < 0.001).
suPAR levels were normalized with creatinine levels (suPAR/creatinine, ng/mg) to remove urine dilution effect.
